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The Oklahoma State Cowboys and the No. 6 Kansas Jayhawks are set to square off in a Big 12 matchup at 8 p.m. ET on Tuesday at Gallagher-Iba Arena. Oklahoma State is 8-3 overall and 3-2 at home, while the Jayhawks are 10-2 overall and 2-0 on the road. Both teams have been mediocre against the spread. Kansas is 5-6 ATS and Oklahoma State has a 5-5 mark. 

The Jayhawks are favored by 3.5 points in the latest Oklahoma State vs. Kansas odds from William Hill Sportsbook, and the over-under is set at 143. Before entering any Kansas vs. Oklahoma State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oklahoma State vs. Kansas. You can head to SportsLine to see its picks. Here are several college basketball odds for Kansas vs. Oklahoma State:

  • Oklahoma State vs. Kansas spread: Oklahoma State +3.5
  • Oklahoma State vs. Kansas over-under: 143 points
  • Oklahoma State vs. Kansas money line: Kansas -170; Oklahoma State +145

What you need to know about Oklahoma State

While not quite a total blowout, the contest between Oklahoma State and the Kansas State Wildcats this past Saturday was still a pretty decisive one as Oklahoma State wrapped it up with a 70-54 win on the road. Oklahoma State got double-digit scores from four players: Guard Isaac Likekele (15), guard Rondel Walker (15), forward Kalib Boone (14), and guard Avery Anderson III (11). Cade Cunningham dished out five assists.

Cunningham, a top NBA prospect, averages 17.8 points, 6.1 rebounds and 3.8 assists. This will be a huge showcase opportunity for him against one of the nation's top programs. 

What you need to know about Kansas

Meanwhile, Kansas narrowly escaped with a victory as the squad got past the Oklahoma Sooners 63-59 in its last game. Forward David McCormack (17 points) was the top scorer for Kansas. It was the second straight win for the Jayhawks after their humiliating 84-59 loss to Texas. Kansas has only dropped that game to the Longhorns and its opener against top-ranked Gonzaga

McCormack is averaging 11.1 points and 5.7 rebounds. Ochai Agbaji is the team's leading scorer at 14.8 ppg, followed closely by Jalen Wilson (14.7 ppg), who is also the team's leading rebounder (8.1 rpg). Though the Jayhawks have several strong options on offense, their real strength has come on the other end where they are giving up just 66.8 points per game. 

How to make Oklahoma State vs. Kansas picks

The model has simulated Oklahoma State vs. Kansas 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Kansas vs. Oklahoma State? And which side of the spread is hitting in well over 50 percent of simulations? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.